Genevant and Takeda to develop novel nonviral gene therapies for rare liver diseases

Genevant Sciences has entered into a global collaboration and license agreement with Takeda the development and commercialisation of novel nonviral gene therapies to treat up to two undisclosed rare liver diseases.

This is the second collaboration between Genevant and Takeda, following an earlier 2021 agreement to develop nucleic acid therapeutics directed to specified targets in hepatic stellate cells to treat liver fibrosis.

“LNP provides a compelling approach to deliver on the promise of gene therapy, and our leadership position in the LNP space is well established,” said Pete Lutwyche, President and CEO of Genevant Sciences Corporation.

“We have enjoyed working with our Takeda colleagues to develop hepatic stellate cell-directed treatments to treat liver fibrosis and are delighted to expand the relationship further with this second collaboration.”

Bernard Allan, head of liver disease research at Takeda, said: “Building on our existing foundation with Genevant in liver fibrosis, we’re excited to expand our work together to develop life-altering, nonviral gene therapies for specified rare liver diseases.

“Genevant’s expertise in the development of LNPs for clinical applications, coupled with Takeda’s drug development capabilities and history in gastroenterology, gives us a great opportunity to develop new treatment options for patients with liver disorders.”

Under the terms of the agreement, Genevant is eligible to receive up to $303 million in upfront and potential milestone payments, plus royalties on future product sales.

Takeda has exclusive rights to utilise Genevant’s LNP technology in the development and commercialisation of specified nonviral gene therapies for up to two undisclosed rare liver diseases.

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