Higher immune response for Zika virus with needle-free delivery

Higher immune response for Zika virus with needle-free delivery
Credit: PharmaJet

Delivery of a Zika virus vaccine via PharmaJet’s needleless injector demonstrated a higher immune response over needle and syringe, according to a study in The Lancet.

Multiple studies have shown that needle-free injectors augment DNA vaccine response, possibly by increased dispersion of injectate or through tissue disruption that increases immunogenicity.

The GMT after split-dose needle-free delivery of VRC5283 was six times higher than single-dose delivery via needle and syringe.

Over 700,000 cases of Zika virus infection have been reported in the Americas since 2015.(2) The emergence of Zika virus has challenged the scientific community to address a relatively uncharacterized pathogen posing a substantial threat to international public health.

The two DNA vaccines assessed in this study were safe and well tolerated, and both were immunogenic. However, the greatest effects were seen with VRC5283 given in split doses via needle-free injection in the VRC 320 trial.

100% of participants who received the vaccine by needle-free injection in split doses had detectable antibody responses, produced neutralizing antibodies, and had the highest T-cell responses.