Sanofi has offered to acquire Kiadis, a Dutch clinical-stage company developing cell-based immunotherapy products for €308 million.
Kiadis’ proprietary platform is based on allogeneic or ‘off-the-shelf’ NK cells from a healthy donor. NK cells seek and identify malignant cancer cells and have broad application across various tumour types.
The platform has the potential to make products rapidly and economically available for a broad patient population across a wide range of indications.
Kiadis’ NK cell-based medicines will be developed alone and in combination with Sanofi’s existing platforms.
Sanofi’s research, development, and commercial expertise will be leveraged to advance Kiadis’ pipeline, which includes NK cell based medicines for the treatment of patients undergoing hematopoietic stem cell transplant, liquid and solid tumors, as well as infectious disease.
In July 2020, Sanofi licensed Kiadis’ pre-clinical K-NK004 program for potential combination for multiple myeloma.
Kiadis’ pipeline of NK cell therapies includes:
- K-NK002 is in a Phase 2 clinical study evaluating NK cells to prevent post-transplant relapse in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes. The Phase 2 trial will be conducted in collaboration with premier U.S. transplant centers.
- K-NK003 is a Phase 1 study evaluating NK cells for patients with relapsed or refractory AML.
- KNK-ID-101 is a program evaluating the properties of K-NK cells and their suitability to fight SARS-CoV-2 and the option to develop K-NK cells as a post-exposure pre-emptive therapy for COVID-19 in high risk patients. Kiadis plans to initiate a phase 1/2a clinical trial evaluating use of K-NK cells to treat COVID-19 patients with government grant funding.