UCB partners with Novartis for Parkinson’s treatments

UCB has entered into a global co-development and co-commercialization agreement with Novartis covering UCB0599, a potential first in class, small molecule, alpha-synuclein misfolding inhibitor currently in Phase 2 clinical development, and upon completion of the ongoing Phase 1 program, an opt-in to co-develop UCB7853, an anti-alpha-synuclein antibody, both in Parkinson’s Disease (PD).

“This partnership has the potential to be transformational for people living with Parkinson’s disease, as it will combine UCB’s expertise as a leader in the field of neurodegenerative disease with Novartis’ global capabilities and deep experience developing transformative, disease modifying treatments for a range of neurological conditions,” said Dhaval Patel, Executive Vice President and Chief Scientific Officer at UCB.

“It is a great example of our approach to research and development in neurodegeneration, building external networks and partnerships to access additional capabilities and knowledge, that help to accelerate the development of our medicines.”

Charl van Zyl, Executive Vice President, Neurology & Head of Europe/International Markets, commented: “It is our long-term ambition to transform the Parkinson’s treatment landscape from the management of symptoms, to treatments that can slow or stop the progression of disease. By sharing resources and working together we think we can best optimize our chances of success and realize our Parkinson’s ambitions.”

Under the terms of the agreement, the parties will co-develop and co-fund the further global development of UCB0599. Novartis also have the right to “opt-in” to engage in global co-development of UCB7853 upon completion of a Phase 1 study currently being run by UCB. Further clinical development would then also be jointly funded and managed.

UCB will receive an upfront payment of US$150 million and is eligible to receive further potential payments with a total consideration approaching US$1.5 billion upon receipt of certain regulatory approvals and satisfying certain development and sales related milestones.

If approved, commercial responsibilities will be split, with UCB being the marketing authorization holder and commercial lead in Europe and Japan, and Novartis in the US and all other territories.

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